I did look a bit further into a couple of weeks ago. The unresponsiveness coincided with disk (write, iirc) queue spiking up by a fair bit. But I couldn't identify any possible causes for it, and my system seems to work normally otherwise.
Perhaps there's a latent issue on my computer that Drox brings about. Or perhaps there's some strange hardware/software issue specific to my setup. Regardless, for now it seems playing Drox isn't feasible on this machine at least.