Drox Operative is also a lot less click-crazy than other action-RPGs...use WASD keys to fly around, and as Bluddy mentioned: autotargeting selects enemies and you just hit the key assigned to attack.
After a weekend bouncing between Drox Operative and Torchlight II (yes, what a great year for pc gaming) I can say that Drox Operative is must less stressful on the ol' index finger.
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